Antitumor agent-87

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Antitumor agent-87 是一种有效的抗肿瘤剂。Antitumor agent-87 对 CYP1A1 表现出高亲和力，Ki 值为 0.23 μM。Antitumor agent-87 显示出抗增殖活性。Antitumor agent-87 诱导细胞周期停滞在 G2/M 期。Antitumor agent-87 显示出抗肿瘤活性。

Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 μM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity.

Cell Proliferation Assay Cell Line:MCF7, HT-29, M21 cells Concentration:0-12500 nM Incubation Time:48 h Result:Showed antiproliferative activity with IC50s of 600, >12500, >12500 nM for MCF7, HT-29, M21 cells, respectively.Cell Cycle Analysis Cell Line:MCF7 cells Concentration:1250 nM Incubation Time:Result:Induced the accumulation of the cells in the G2/M phase of 57% and induced disruptions of the cytoskeleton of MCF7 cells.

Animal Model:chick embryos (HT-1080CYP1A1, HT-1080empty, HT-1080 cells) Dosage:0.1 μg/egg Administration:Result:Did not show statistically significant antitumor activity on grafted cell lines devoid of CYP1A1 (HT-1080 and HT-1080empty), showed antitumoral inhibition of 29% on the grafted HT-1080CYP1A1.

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Others

Other Targets

Others

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1422527-88-5

448.53

C22H28N2O6S

>98% (HPLC)

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O=C1N(C2=CC=C(C=C2)S(=O)(=O)OC=3C=C(OC)C=C(OC)C3)CCN1CCCCC

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(-20℃)

With Ice Pack

≥ 2 years